Li Shuping, Zhou Yanjie, Hu Tingting, Li Mei, Luo Yao, Chen Jie
Department of Laboratory Medicine/Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Front Immunol. 2025 May 15;16:1592314. doi: 10.3389/fimmu.2025.1592314. eCollection 2025.
Migrasomes are newly discovered extracellular organelles released by migrating cells, such as immune cells, tumor cells, and other special functional cells like podocytes and embryonic cells. They contain a diverse array of constituents, including proteins, lipids, and RNA which can be released to the designated location to activate surrounding cells, thereby facilitating intercellular communication and signal transduction. Since then, our understanding of the mechanism and function of the migrasomes has expanded exponentially, with recent evidence indicating they are involved in various physiological and pathological processes, particularly in immune regulation. Furthermore, methods and techniques for extracting, detecting, and characterizing migrasomes are constantly advancing. Herein, we summarize the current understanding of migrasomes and their key roles in modulating immune responses, as well as the prospective challenges surrounding their clinical application, aiming to provide novel insights into the emerging organelles.
迁移小体是新发现的由迁移细胞释放的细胞外细胞器，这些迁移细胞包括免疫细胞、肿瘤细胞以及其他特殊功能细胞，如足细胞和胚胎细胞。它们含有多种成分，包括蛋白质、脂质和RNA，这些成分可以释放到指定位置以激活周围细胞，从而促进细胞间通讯和信号转导。从那时起，我们对迁移小体的机制和功能的理解呈指数级增长，最近有证据表明它们参与了各种生理和病理过程，特别是在免疫调节方面。此外，用于提取、检测和表征迁移小体的方法和技术也在不断进步。在此，我们总结了目前对迁移小体的认识及其在调节免疫反应中的关键作用，以及围绕其临床应用的潜在挑战，旨在为这一新兴细胞器提供新的见解。
