Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
Cold Spring Harb Perspect Biol. 2011 May 1;3(5):a005033. doi: 10.1101/cshperspect.a005033.
Cell adhesions mediate important bidirectional interactions between cells and the extracellular matrix. They provide an interactive interface between the extracellular chemical and physical environment and the cellular scaffolding and signaling machinery. This dynamic, reciprocal regulation of intracellular processes and the matrix is mediated by membrane receptors such as the integrins, as well as many other components that comprise the adhesome. Adhesome constituents assemble themselves into different types of cell adhesion structures that vary in molecular complexity and change over time. These cell adhesions play crucial roles in cell migration, proliferation, and determination of cell fate.
细胞黏附介导细胞与细胞外基质之间的重要双向相互作用。它们在细胞外的化学和物理环境与细胞支架和信号转导机制之间提供了一个相互作用的界面。这种细胞内过程和基质的动态、相互调节是由膜受体（如整合素）以及构成黏着斑的许多其他成分介导的。黏着斑成分组装成不同类型的细胞黏附结构，这些结构在分子复杂性上有所不同，并随时间而变化。这些细胞黏附在细胞迁移、增殖和细胞命运决定中起着至关重要的作用。
