Department of Head and Neck Tumor Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Head Neck. 2014 Jan;36(1):71-6. doi: 10.1002/hed.23261. Epub 2013 Jun 1.
Prognostic value of serum cytokeratin fraction 21-1 (CYFRA 21-1) has not been fully validated for nasopharyngeal carcinoma (NPC).
Serum CYFRA 21-1 levels of 332 patients with NPC were measured before treatment, and their association with overall survival (OS), tumor-free survival (TFS), time to local recurrence (TLR), and time to distant recurrence (TDR) was studied.
Pretreatment serum CYFRA 21-1 level of patients with classification of T1+2 , N0 , stage I+II was significantly lower than that of those with T3+4 , N1+2+3 and III+IV, respectively. Multivariate analysis showed that a high pretreatment serum level of CYFRA 21-1 and T classification were independent predictors of poor OS and TDR. A high pretreatment level of CYFRA 21-1 was an independent predictor of shorter TFS and TLR.
The pretreatment serum level of CYFRA 21-1 would be a reliable biomarker to evaluate the long-term prognosis of patients with undifferentiated NPC.
血清细胞角蛋白片段 21-1（CYFRA 21-1）对鼻咽癌（NPC）的预后价值尚未得到充分验证。
检测 332 例 NPC 患者治疗前的血清 CYFRA 21-1 水平，并研究其与总生存（OS）、无瘤生存（TFS）、局部复发时间（TLR）和远处复发时间（TDR）的关系。
T1+2、N0、I+II 期患者的血清 CYFRA 21-1 水平显著低于 T3+4、N1+2+3 和 III+IV 期患者。多因素分析显示，高血清 CYFRA 21-1 水平和 T 分类是 OS 和 TDR 不良的独立预测因素。高血清 CYFRA 21-1 水平是 TFS 和 TLR 较短的独立预测因素。
治疗前血清 CYFRA 21-1 水平可作为评估未分化 NPC 患者长期预后的可靠生物标志物。
