Molecular Medicine Area, Regina Elena National Cancer Institute, Rome, Italy.
Mol Cancer Ther. 2013 Jun;12(6):844-52. doi: 10.1158/1535-7163.MCT-12-1103. Epub 2013 May 31.
Malignant mesothelioma or mesothelioma is a rare form of cancer that develops from transformed cells originating in the mesothelium, the protective lining that covers many of the internal organs of the body. It is directly linked to asbestos exposure, which acts as a carcinogen by initiating the carcinogenic process. Because of their shape, asbestos fibers can cross the membrane barriers inside the body and cause inflammatory and fibrotic reactions. Such reactions are believed to be the mechanism by which asbestos fibers may trigger malignant mesothelioma in the pleural membrane around the lungs. Carcinogens are known to modulate the transcription factors, antiapoptotic proteins, proapoptotic proteins, protein kinases, cell-cycle proteins, cell adhesion molecules, COX-2, and growth factor signaling pathways. This article reviews recent studies regarding some malignant mesothelioma molecular targets not only for cancer prevention but also for cancer therapy.
恶性间皮瘤或间皮瘤是一种罕见的癌症，它起源于间皮细胞的转化细胞，间皮是覆盖身体许多内部器官的保护层。它与石棉暴露直接相关，石棉作为一种致癌物质，通过引发致癌过程而起作用。由于其形状，石棉纤维可以穿过体内的膜屏障，引起炎症和纤维性反应。这种反应被认为是石棉纤维在肺部周围的胸膜中引发恶性间皮瘤的机制。致癌物质已知可以调节转录因子、抗凋亡蛋白、促凋亡蛋白、蛋白激酶、细胞周期蛋白、细胞黏附分子、COX-2 和生长因子信号通路。本文综述了最近关于恶性间皮瘤一些分子靶点的研究，这些靶点不仅可用于癌症预防，也可用于癌症治疗。
