University of Miami, Miami, FL, USA.
Integr Cancer Ther. 2014 Jan;13(1):38-45. doi: 10.1177/1534735413490235. Epub 2013 May 31.
Radiation-induced skin damage is one of the most common complications of radiotherapy. In order to combat these side effects, patients often turn to alternative therapies, which often include antioxidants. Antioxidants such as those in the polyphenol chemical class, xanthine derivatives, tocepherol, sucralfate, and ascorbate have been studied for their use in either preventing or treating radiotherapy-induced skin damage. Apart from their known role as free radical scavengers, some of these antioxidants appear to alter cytokine release affecting cutaneous and systemic changes. We review the role of antioxidants in treating and preventing radiation-induced skin damage as well as the possible complications of using such therapy.
辐射引起的皮肤损伤是放射治疗中最常见的并发症之一。为了对抗这些副作用，患者通常会转向替代疗法，其中通常包括抗氧化剂。研究表明，多酚化学类、黄嘌呤衍生物、生育酚、蔗糖硫酸酯和抗坏血酸等抗氧化剂可用于预防或治疗放射治疗引起的皮肤损伤。除了已知的自由基清除剂作用外，这些抗氧化剂中的一些似乎还改变细胞因子释放，影响皮肤和全身变化。我们综述了抗氧化剂在治疗和预防放射性皮肤损伤中的作用，以及使用这种治疗方法可能出现的并发症。
