Departments of Breast Medical Oncology; Melanoma Medical Oncology.
Systems Biology.
Ann Oncol. 2013 Oct;24(10):2534-2542. doi: 10.1093/annonc/mdt190. Epub 2013 May 31.
TRPS-1 is a new GATA transcription factor that is differentially expressed in breast cancer (BC) where it been found recently to regulate epithelial-to-mesenchymal transition (EMT).
We carried out a quantitative immunohistochemistry (qIHC) analysis of TRPS-1 expression in 341 primary-stage I-III BC samples in relation to patient clinical characteristics as well as its prognostic value, especially in an estrogen receptor-positive (ER+) subgroup.
Higher TRPS-1 expression was significantly associated with a number of clinical and pathological characteristics as well as with improved overall survival (OS) and disease-free survival (DFS). Among stage I/II ER+ BC patients who received endocrine therapy alone, those with high TRPS-1 expression had significantly longer OS and DFS. There was also a strong association between TRPS-1 levels and the EMT marker E-cadherin in the ER+ invasive ductal carcinoma cases. Analysis of gene expression data on a panel of BC lines found that TRPS-1 expression was low or absent in BC lines having enriched mesenchymal features.
Our data indicated that TRPS-1 is an independent prognostic marker in early-stage BC and a new EMT marker that can distinguish patients with ER+ BC who will respond longer to adjuvant endocrine therapy.
TRPS-1 是一种新的 GATA 转录因子，在乳腺癌（BC）中差异表达，最近发现它可调节上皮间质转化（EMT）。
我们对 341 例 I-III 期原发性 BC 样本进行了 TRPS-1 表达的定量免疫组化（qIHC）分析，以评估其与患者临床特征的关系及其预后价值，特别是在雌激素受体阳性（ER+）亚组中。
较高的 TRPS-1 表达与多种临床和病理特征显著相关，与总生存期（OS）和无病生存期（DFS）的改善相关。在接受单独内分泌治疗的 I/II 期 ER+BC 患者中，高 TRPS-1 表达者的 OS 和 DFS 显著延长。在 ER+浸润性导管癌病例中，TRPS-1 水平与 EMT 标志物 E-钙黏蛋白之间也存在很强的相关性。对一组 BC 细胞系的基因表达数据分析发现，具有丰富间质特征的 BC 细胞系中 TRPS-1 表达水平较低或缺失。
我们的数据表明，TRPS-1 是早期 BC 的独立预后标志物，也是一种新的 EMT 标志物，可区分出对辅助内分泌治疗反应更长的 ER+BC 患者。
