Department of Pathology, Shandong University School of Medicine, 44#, Wenhua Xi Road, 250012 Jinan, Shandong, P,R, China.
Diagn Pathol. 2014 Jun 16;9:119. doi: 10.1186/1746-1596-9-119.
Breast cancer is a heterogeneous disease consisting of different subtypes. Trichorhinophalangeal syndrome type 1 (TRPS1) gene, a GATA-type transcription factor, has been found to be highly expressed in breast cancer. Epithelial-to-mesenchymal transition (EMT) is known to play an important role in tumour invasion and metastasis. Our objective was to elucidate the different roles and clinical relevance of TRPS1 in different estrogen receptor (ER) expression subtypes of breast cancer.
An immunohistochemical study was performed. The correlation between clinicopathological features and other biomarker profiles were analysed statistically.
TRPS1 expression was correlated with the patients' age (P=0.017). It was positively related with ERα (P<0.001), progesterone receptor (PR) (P<0.001) and ERβ (P=0.001) status, but negatively associated with Ki67 (P=0.002) and HER2 (P=0.025) status. In ERα-positive breast cancer, TRPS1 expression was positively associated with the expression of E-cadherin (P<0.001), β-catenin(P=0.001), ERβ (P=0.03), and p53 (P=0.002) status, while in ERα-negative breast cancer, TRPS1 expression was correlated with slug (P=0.004), vimentin (P=0.003), smooth muscle actin (SMA) (P=0.031), and IMP3 (P=0.005) expression.
Based on our findings, we conclude that TRPS1 is positively associated with E-cadherin and β-catenin status in ERα-positive breast cancer cells, while it is also significantly associated with mesenchymal markers of EMT in ERα-negative breast cancer cells. TRPS1 can be a prognostic marker depending on the type of breast cancer.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8686515681264281.
乳腺癌是一种由不同亚型组成的异质性疾病。TRPS1 基因（一种 GATA 型转录因子）已被发现高度表达于乳腺癌中。上皮-间质转化（EMT）在肿瘤侵袭和转移中起着重要作用。我们的目的是阐明 TRPS1 在不同雌激素受体（ER）表达亚型的乳腺癌中的不同作用和临床相关性。
进行了免疫组织化学研究。统计分析了临床病理特征与其他生物标志物特征之间的相关性。
TRPS1 表达与患者年龄相关（P=0.017）。它与 ERα（P<0.001）、孕激素受体（PR）（P<0.001）和 ERβ（P=0.001）状态呈正相关，而与 Ki67（P=0.002）和 HER2（P=0.025）状态呈负相关。在 ERα 阳性乳腺癌中，TRPS1 表达与 E-钙黏蛋白（P<0.001）、β-连环蛋白（P=0.001）、ERβ（P=0.03）和 p53（P=0.002）的表达呈正相关，而在 ERα 阴性乳腺癌中，TRPS1 表达与 slug（P=0.004）、波形蛋白（P=0.003）、平滑肌肌动蛋白（SMA）（P=0.031）和 IMP3（P=0.005）的表达相关。
根据我们的发现，我们得出结论，TRPS1 在 ERα 阳性乳腺癌细胞中与 E-钙黏蛋白和β-连环蛋白状态呈正相关，而在 ERα 阴性乳腺癌细胞中与 EMT 的间充质标志物显著相关。TRPS1 可作为一种预后标志物，取决于乳腺癌的类型。
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