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CrossTalk proposal: there is added benefit to providing permissive hypercapnia in the treatment of ARDS.

作者信息

Curley Gerard F, Laffey John G, Kavanagh Brian P

机构信息

Department of Anesthesia, Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, Ontario, Canada.

出版信息

J Physiol. 2013 Jun 1;591(11):2763-5. doi: 10.1113/jphysiol.2013.252601.

DOI:10.1113/jphysiol.2013.252601
PMID:23729790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3690679/
Abstract
摘要

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CrossTalk proposal: there is added benefit to providing permissive hypercapnia in the treatment of ARDS.串扰假说：在急性呼吸窘迫综合征（ARDS）治疗中采用允许性高碳酸血症有额外益处。
J Physiol. 2013 Jun 1;591(11):2763-5. doi: 10.1113/jphysiol.2013.252601.
2
CrossTalk opposing view: there is not added benefit to providing permissive hypercapnia in the treatment of ARDS.相互矛盾的观点：在急性呼吸窘迫综合征（ARDS）的治疗中采用允许性高碳酸血症并无额外益处。
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本文引用的文献

1
Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κB-dependent mechanism.高碳酸酸中毒通过核因子-κB 依赖性机制减轻通气诱导的肺损伤。
Crit Care Med. 2012 Sep;40(9):2622-30. doi: 10.1097/CCM.0b013e318258f8b4.
2
NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells.核因子κB将二氧化碳感知与哺乳动物细胞的先天免疫和炎症联系起来。
J Immunol. 2010 Oct 1;185(7):4439-45. doi: 10.4049/jimmunol.1000701. Epub 2010 Sep 3.
3
Therapeutic effects of hypercapnia on chronic lung injury and vascular remodeling in neonatal rats.高碳酸血症对新生大鼠慢性肺损伤及血管重塑的治疗作用。
Am J Physiol Lung Cell Mol Physiol. 2009 Nov;297(5):L920-30. doi: 10.1152/ajplung.00139.2009. Epub 2009 Sep 11.
4
Impact of acute hypercapnia and augmented positive end-expiratory pressure on right ventricle function in severe acute respiratory distress syndrome.急性高碳酸血症和呼气末正压通气对严重急性呼吸窘迫综合征右心功能的影响。
Intensive Care Med. 2009 Nov;35(11):1850-8. doi: 10.1007/s00134-009-1569-2. Epub 2009 Aug 4.
5
Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism.高碳酸酸中毒通过 NF-κB 依赖机制减弱肺上皮细胞的伤口修复。
Thorax. 2009 Nov;64(11):976-82. doi: 10.1136/thx.2008.110304. Epub 2009 Jul 16.
6
Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis.高碳酸血症性酸中毒可减轻早期和持续性全身脓毒症中的休克和肺损伤。
Crit Care Med. 2009 Aug;37(8):2412-20. doi: 10.1097/CCM.0b013e3181a385d3.
7
Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia.高碳酸血症性酸中毒减轻已确诊的细菌性肺炎所致的肺损伤。
Anesthesiology. 2008 Nov;109(5):837-48. doi: 10.1097/ALN.0b013e3181895fb7.
8
Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism.高碳酸血症性酸中毒通过一种不依赖中性粒细胞的机制减轻严重急性细菌性肺炎所致的肺损伤。
Crit Care Med. 2008 Dec;36(12):3135-44. doi: 10.1097/CCM.0b013e31818f0d13.
9
Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury.肺部感染期间持续的高碳酸血症性酸中毒会增加细菌载量并加重肺损伤。
Crit Care Med. 2008 Jul;36(7):2128-35. doi: 10.1097/CCM.0b013e31817d1b59.
10
Effects of a clinical trial on mechanical ventilation practices in patients with acute lung injury.一项临床试验对急性肺损伤患者机械通气实践的影响。
Am J Respir Crit Care Med. 2008 Jun 1;177(11):1215-22. doi: 10.1164/rccm.200709-1424OC. Epub 2008 Mar 20.