0.05%局部用环孢素对白内障术后干眼的影响。
The effect of topical cyclosporine 0.05% on dry eye after cataract surgery.
作者信息
Chung Yeon Woong, Oh Tae Hoon, Chung Sung Kun
机构信息
Department of Ophthalmology, Yeouido St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
出版信息
Korean J Ophthalmol. 2013 Jun;27(3):167-71. doi: 10.3341/kjo.2013.27.3.167. Epub 2013 Apr 8.
PURPOSE
To evaluate the effectiveness of cyclosporine 0.05% for dry eye after cataract surgery.
METHODS
Thirty-two newly diagnosed patients with dry eye syndrome 1 week after cataract surgery received a twice-daily treatment of cyclosporine 0.05% for one eye and normal saline 0.9% for the other. Disease severity was measured at 2 weeks, 1 month, 2 months, and 3 months by Schirmer test I (ST-I), tear film break-up time (tBUT), corneal temperature and dry eye symptom questionnaire (Ocular Surface Disease Index).
RESULTS
Both groups increased in ST-I and tBUT over time. ST-I in the cyclosporine 0.05% group showed a significant increase at 3 months and tBUT in the cyclosporine 0.05% group showed an increase at 2 and 3 months. The dry eye symptom score was significantly reduced in the cyclosporine 0.05% group.
CONCLUSIONS
Cyclosporine 0.05% can also be an effective treatment for dry eye after cataract surgery.
目的
评估0.05%环孢素治疗白内障术后干眼的有效性。
方法
32例白内障术后1周新诊断为干眼综合征的患者，一只眼睛每日接受两次0.05%环孢素治疗，另一只眼睛接受0.9%生理盐水治疗。在2周、1个月、2个月和3个月时，通过I型泪液分泌试验（ST-I）、泪膜破裂时间（tBUT）、角膜温度和干眼症状问卷（眼表疾病指数）测量疾病严重程度。
结果
两组的ST-I和tBUT均随时间增加。0.05%环孢素组的ST-I在3个月时显著增加，0.05%环孢素组的tBUT在2个月和3个月时增加。0.05%环孢素组的干眼症状评分显著降低。
结论
0.05%环孢素也可有效治疗白内障术后干眼。
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