Department of Chemistry and Biochemistry, San Diego State University, San Diego CA 92182 USA.
Curr Neuropharmacol. 2012 Dec;10(4):289-302. doi: 10.2174/157015912804143487.
Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson's, Huntington's, Alzheimer's, prions, Down's syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.
人们对涉及氧化还原过程的神经退行性疾病给予了极大关注。本综述包含了近年来氧化还原过程的大量文献更新。该机制涉及活性氧和氧化应激，通常发生在大脑中。有许多例子，包括帕金森病、亨廷顿病、阿尔茨海默病、朊病毒、唐氏综合征、共济失调、多发性硬化症、克雅氏病、肌萎缩侧索硬化症、精神分裂症和迟发性运动障碍。有证据表明抗氧化剂具有保护作用，这可能具有临床意义。对作用方式采取多方面的方法似乎是合理的。
