Shenoy Ashok M, Prashanth V, Shivakumar T, Chavan Purushottam, Akshay S, Kumar Rekha V, Devi Saraswati
Department of Head and Neck Oncology, Kidwai Memorial Institute of Oncology, Bangalore, India.
Indian J Otolaryngol Head Neck Surg. 2012 Jun;64(2):137-41. doi: 10.1007/s12070-012-0496-7. Epub 2012 Feb 11.
In the past few decades more and more number of tumors of the glottis and supraglottis are been treated with single stage transoral laser microsurgery (TOLS). TOLS for the treatment of glottic and supraglottic carcinoma with anterior commissure (A-com) and/paraglottic space involvement is associated with a high rate of recurrence. We prospectively evaluated the outcomes of laser microsurgery and the impact of second look operation in these patients. Twenty-three patients with glottic and supraglottic carcinoma underwent transoral laser micro resection of the lesions. Subsequently five patients underwent second look microlaryngeal evaluation 6-8 months later for non-satisfactory healing, poor voice, and or suspicion of recurrent disease. Patients with A-com involvement and or paraglottic space involvement were followed up longitudinally for the effectiveness and timing of second look microsurgery. After initial transoral laser micro resection, all patients achieved microscopically clear resection margins. At second look microlaryngeal evaluation, local recurrence was found in four of 23 patients. Of these, two patients were salvaged by second look surgery and are disease free, whereas in two others, the larynx had to be subjected to open surgical intervention. One of two had extensive local recurrent tumor and underwent total laryngectomy with neck dissection followed by post-operative radiotherapy. Tracheohyoidopexy was done with successful functional and oncologic outcome for another patient who had local recurrence for the third time. Only the patient who underwent total laryngectomy with neck dissection was subjected to adjuvant post-operative radiotherapy. Finally, larynx was saved in 21 out of 23 patients.
在过去几十年中,越来越多的声门和声门上肿瘤采用单阶段经口激光显微手术(TOLS)进行治疗。TOLS 用于治疗累及前联合(A-com)和声门旁间隙的声门和声门上癌,其复发率较高。我们前瞻性地评估了这些患者激光显微手术的结果以及二次探查手术的影响。23 例声门和声门上癌患者接受了经口激光显微切除病变手术。随后,5 例患者因愈合不佳、声音差或怀疑疾病复发,在 6 - 8 个月后接受了二次喉显微评估。对累及 A-com 和声门旁间隙的患者进行纵向随访,观察二次探查显微手术的有效性和时机。初次经口激光显微切除术后,所有患者显微镜下切缘均清晰。二次喉显微评估时,23 例患者中有 4 例发现局部复发。其中,2 例患者通过二次探查手术挽救,目前无疾病;而另外 2 例患者,不得不接受开放性手术干预。其中 1 例有广泛的局部复发性肿瘤,接受了全喉切除术加颈部清扫术,随后进行术后放疗。对于另 1 例第三次出现局部复发的患者,进行了气管舌骨固定术,功能和肿瘤学结果均成功。只有接受全喉切除术加颈部清扫术的患者接受了辅助性术后放疗。最后,23 例患者中有 21 例保住了喉部。