大麻环萜醇、克洛西环萜醇 A 和 B、异埃里布瑞醇 A 和 B 以及埃里布瑞醇的全合成。
Total syntheses of cannabicyclol, clusiacyclol A and B, iso-eriobrucinol A and B, and eriobrucinol.
机构信息
Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin , Madison, Wisconsin 53705, United States, and School of Pharmaceutical Science and Technology, Tianjin University , Tianjin, 300072, P. R. China.
出版信息
Org Lett. 2013 Jun 21;15(12):3130-3. doi: 10.1021/ol401335u. Epub 2013 Jun 3.
Total syntheses of a series of chromane natural products that contain a cyclobutane ring are described. A unified theme in the strategy employed for all these syntheses is an oxa-[3 + 3] annulation for constructing the chromane nucleus and a stepwise cationic [2 + 2] cycloaddition for the cyclobutane formation. More importantly, the two reactions could be rendered in tandem, thereby providing an expeditious approach to this family of natural products.
描述了一系列含有环丁烷环的色烷天然产物的全合成。在所有这些合成中采用的策略的一个统一主题是通过氧杂-[3 + 3] 环化反应构建色烷核，以及逐步的阳离子[2 + 2]环加成反应形成环丁烷。更重要的是，这两个反应可以串联进行，从而为这一系列天然产物提供了一种快速的合成方法。
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