Saleemi Mansab Ali, Yahaya Noorfatimah, Zain Nur Nadhirah Mohamad, Raoov Muggundha, Yong Yoke Keong, Noor Nurul Shahfiza, Lim Vuanghao
Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, Penang, Malaysia.
Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Selangor, Malaysia.
Pharmaceuticals (Basel). 2022 Oct 6;15(10):1228. doi: 10.3390/ph15101228.
The development of new antibiotics is urgently needed to combat the threat of bacterial resistance. New classes of compounds that have novel properties are urgently needed for the development of effective antimicrobial agents. The extract of L. has been used to treat multiple ailments since ancient times. Its bioactivity is largely attributed to the cannabinoids found in its plant. Researchers are currently searching for new anti-infective agents that can treat various infections. Although its phytocannabinoid ingredients have a wide range of medical benefits beyond the treatment of infections, they are primarily associated to psychotropic effects. Different cannabinoids have been demonstrated to be helpful against harmful bacteria, including Gram-positive bacteria. Moreover, combination therapy involving the use of different antibiotics has shown synergism and broad-spectrum activity. The purpose of this review is to gather current data on the actions of () extracts and its primary constituents such as terpenes and cannabinoids towards pathogens in order to determine their antimicrobial properties and cytotoxic effects together with current challenges and future perspectives in biomedical application.
迫切需要开发新的抗生素来应对细菌耐药性的威胁。开发有效的抗菌剂迫切需要具有新特性的新型化合物类别。自古以来，L. 的提取物就被用于治疗多种疾病。其生物活性在很大程度上归因于其植物中发现的大麻素。研究人员目前正在寻找能够治疗各种感染的新型抗感染剂。尽管其植物大麻素成分除了治疗感染外还有广泛的医学益处，但它们主要与精神作用有关。已证明不同的大麻素对有害细菌（包括革兰氏阳性菌）有帮助。此外，涉及使用不同抗生素的联合疗法已显示出协同作用和广谱活性。本综述的目的是收集有关（）提取物及其主要成分（如萜类化合物和大麻素）对病原体作用的当前数据，以确定它们的抗菌特性和细胞毒性作用，以及生物医学应用中的当前挑战和未来前景。
