通过腈的氢锆化-酰化-环化级联反应构建螺环氧化吲哚酰胺库。
Construction of a spirooxindole amide library through nitrile hydrozirconation-acylation-cyclization cascade.
机构信息
Department of Chemistry, Chemical Methodologies and Library Development, and ‡Department of Pharmaceutical Sciences, School of Pharmacy, Computational Chemical Genomics Screening Center, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
出版信息
ACS Comb Sci. 2013 Jul 8;15(7):344-9. doi: 10.1021/co4000387. Epub 2013 Jun 26.
Abstract
A library of spirooxindoles containing varied elements of structural and stereochemical diversity has been constructed via a three step, one pot nitrile hydrozirconation-acylation-cyclization reaction sequence from common acyclic indole intermediates. The resulting library was evaluated for novelty through comparison with MLSMR and Maybridge compound collections.
摘要
通过三步一锅的腈基氢锆化-酰化-环化反应序列，从常见的无环吲哚中间体构建了一个含有结构和立体化学多样性的螺环氧化吲哚文库。通过与 MLSMR 和 Maybridge 化合物集的比较，对所得文库进行了新颖性评估。
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