Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, Boston, Massachusetts 02215, USA.
Org Lett. 2010 Feb 5;12(3):572-5. doi: 10.1021/ol902764k.
The Lewis acid-catalyzed, three-component reaction of isatin and two 1,3-dicarbonyl compounds is reported. Reactions proceed with high efficiency under mild reaction conditions and with good functional group tolerance to afford spirooxindole pyranochromenedione derivatives.
报道了路易斯酸催化的靛红与两个 1,3-二羰基化合物的三组分反应。反应在温和的反应条件下以高效率进行,并且具有良好的官能团耐受性,可得到螺[吲哚啉-3,3'-吡喃并[2,3-d]色烯-6,2'-二酮]衍生物。