Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Microbiology, University of Washington, Seattle, WA 98105 USA.
Virology. 2013 Oct;445(1-2):138-68. doi: 10.1016/j.virol.2013.04.013. Epub 2013 May 31.
E7 is an accessory protein that is not encoded by all papillomaviruses. The E7 amino terminus contains two regions of similarity to conserved regions 1 and 2 of the adenovirus E1A protein, which are also conserved in the simian vacuolating virus 40 large tumor antigen. The E7 carboxyl terminus consists of a zinc-binding motif, which is related to similar motifs in E6 proteins. E7 proteins play a central role in the human papillomavirus life cycle, reprogramming the cellular environment to be conducive to viral replication. E7 proteins encoded by the cancer-associated alpha human papillomaviruses have potent transforming activities, which together with E6, are necessary but not sufficient to render their host squamous epithelial cell tumorigenic. This article strives to provide a comprehensive summary of the published research studies on human papillomavirus E7 proteins.
E7 是一种辅助蛋白，并非所有乳头瘤病毒都编码该蛋白。E7 氨基末端含有两个与腺病毒 E1A 蛋白的保守区域 1 和 2 相似的区域，这两个区域在猿猴空泡病毒 40 大肿瘤抗原中也保守。E7 羧基末端由一个锌结合基序组成，该基序与 E6 蛋白中的类似基序相关。E7 蛋白在人类乳头瘤病毒生命周期中发挥核心作用，重新编程细胞环境以有利于病毒复制。与癌症相关的 α 型人类乳头瘤病毒编码的 E7 蛋白具有很强的转化活性，与 E6 蛋白一起，是使其宿主鳞状上皮细胞发生肿瘤所必需的，但不是充分的条件。本文旨在对人类乳头瘤病毒 E7 蛋白的已发表研究进行全面总结。
