*National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark †Department of Medical Gastroenterology, Hvidovre Hospital, Copenhagen University Hospital, Copenhagen, Denmark ‡Unit of Medical Psychology, Department of Public Health, University of Copenhagen, Denmark.
Ann Surg. 2013 Dec;258(6):930-42. doi: 10.1097/SLA.0b013e3182988d59.
To systematically review and summarize the evidence of the association between preoperative alcohol consumption and postoperative complications elaborated on complication type.
Conclusions in studies on preoperative alcohol consumption and postoperative complications have been inconsistent.
A systematic review and meta-analysis based on a search in MEDLINE, EMBASE, CINAHL, and PsycINFO citations. Included were original studies of the association between preoperative alcohol consumption and postoperative complications occurring within 30 days of the operation. In total, 3676 studies were identified and reviewed for eligibility, and data were extracted. Forest plots and pooled relative risks (RRs), including 95% confidence intervals (CIs), were estimated for several complication types.
Fifty-five studies provided data for estimates. Preoperative alcohol consumption was associated with an increased risk of various postoperative complications, including general morbidity (RR = 1.56; 95% CI: 1.31-1.87), general infections (RR = 1.73; 95% CI: 1.32-2.28), wound complications (RR = 1.23; 95% CI: 1.09-1.40), pulmonary complications (RR = 1.80; 95% CI: 1.30-2.49), prolonged stay at the hospital (RR = 1.24; 95% CI: 1.18-1.31), and admission to intensive care unit (RR = 1.29; 95% CI: 1.03-1.61). Clearly defined high alcohol consumption was associated with increased risk of postoperative mortality (RR = 2.68; 95% CI: 1.50-4.78). Low to moderate preoperative alcohol consumption and postoperative complications did not seem to be associated; however, very few studies were included in the analyses hereof.
Preoperative alcohol consumption was associated with an increased risk of general postoperative morbidity, general infections, wound complications, pulmonary complications, prolonged stay at the hospital, and admission to intensive care unit.
系统回顾和总结术前饮酒与术后并发症之间关系的证据，并详细说明并发症类型。
关于术前饮酒与术后并发症的研究结论一直不一致。
基于 MEDLINE、EMBASE、CINAHL 和 PsycINFO 引文的系统综述和荟萃分析。纳入了术前饮酒与术后 30 天内发生的并发症之间关联的原始研究。共确定并审查了 3676 项研究的资格，并提取了数据。针对几种并发症类型，估计了森林图和汇总相对风险（RR）及其 95%置信区间（CI）。
55 项研究提供了数据估计。术前饮酒与多种术后并发症的风险增加相关，包括一般发病率（RR=1.56；95%CI：1.31-1.87）、一般感染（RR=1.73；95%CI：1.32-2.28）、伤口并发症（RR=1.23；95%CI：1.09-1.40）、肺部并发症（RR=1.80；95%CI：1.30-2.49）、住院时间延长（RR=1.24；95%CI：1.18-1.31）和入住重症监护病房（RR=1.29；95%CI：1.03-1.61）。明确界定的大量饮酒与术后死亡率增加相关（RR=2.68；95%CI：1.50-4.78）。低至中度术前饮酒与术后并发症似乎没有关联，但在此分析中纳入的研究非常少。
术前饮酒与一般术后发病率、一般感染、伤口并发症、肺部并发症、住院时间延长和入住重症监护病房的风险增加相关。
