Crintea Andreea, Carpa Rahela, Mitre Andrei-Otto, Petho Robert Istvan, Chelaru Vlad-Florin, Nădășan Sebastian-Mihail, Neamti Lidia, Dutu Alina Gabriela
Department of Medical Biochemistry, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Department of Molecular Biology and Biotechnology, Faculty of Biology and Geology, Babes-Bolyai University, 400084 Cluj-Napoca, Romania.
Nanomaterials (Basel). 2023 Jan 30;13(3):555. doi: 10.3390/nano13030555.
Considered as the most frequent contaminations that do not require hospitalization, urinary tract infections (UTIs) are largely known to cause significant personal burdens on patients. Although UTIs overall are highly preventable health issues, the recourse to antibiotics as drug treatments for these infections is a worryingly spread approach that should be addressed and gradually overcome in a contemporary, modernized healthcare system. With a virtually alarming global rise of antibiotic resistance overall, nanotechnologies may prove to be the much-needed 'lifebuoy' that will eventually suppress this prejudicial phenomenon. This review aims to present the most promising, currently known nano-solutions, with glimpses on clinical and epidemiological aspects of the UTIs, prospective diagnostic instruments, and non-antibiotic treatments, all of these engulfed in a comprehensive overview.
作为最常见的无需住院治疗的感染，尿路感染（UTIs）在很大程度上被认为会给患者带来巨大的个人负担。尽管尿路感染总体上是高度可预防的健康问题，但将抗生素作为这些感染的药物治疗手段的做法却令人担忧地广泛存在，在当代现代化医疗体系中，这一问题应得到解决并逐步克服。鉴于全球抗生素耐药性几乎呈惊人的上升趋势，纳米技术可能被证明是最终抑制这一有害现象所需的“救命稻草”。本综述旨在介绍最有前景的、目前已知的纳米解决方案，并简要介绍尿路感染的临床和流行病学方面、前瞻性诊断工具以及非抗生素治疗方法，所有这些都包含在一个全面的概述中。
