口腔癌患者治疗前循环单核细胞计数与预后不良相关。
Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer.
作者信息
Tsai Yu-Duan, Wang Chao-Ping, Chen Chih-Yu, Lin Li-Wen, Hwang Tzer-Zen, Lu Li-Fen, Hsu Hsia-Fen, Chung Fu-Mei, Lee Yau-Jiunn, Houng Jer-Yiing
机构信息
Division of Neurology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan; Department of Medical Nutrition, Institute of Biotechnology and Chemical Engineering and I-Shou University, Kaohsiung, Taiwan.
出版信息
Head Neck. 2014 Jul;36(7):947-53. doi: 10.1002/hed.23400. Epub 2014 Jan 16.
BACKGROUND
The purpose of this study was to investigate whether the pretreatment total and differential leukocyte counts can predict the prognosis of patients with oral cavity cancer.
METHODS
In a retrospective analysis of patients treated between 2004 and 2011, medical records of 202 patients with oral cavity cancer were evaluated.
RESULTS
Patients with oral cavity cancer, the peripheral total white blood cell (WBC) count, monocyte, and neutrophil counts and neutrophil lymphocyte ratio increased with the advancement of clinical stage. In contrast, the lymphocyte count decreased. Further, total WBC, monocyte, and neutrophil counts were increased in those with pathologic stage T4 and poor tumor differentiation, and the monocyte count was also increased in those with lymph node metastasis. Moreover, the pretreatment circulating monocyte count was an independent prognostic factor for cancer-specific survival.
CONCLUSION
A higher pretreatment circulating monocyte count can be considered as a useful prognostic marker in patients with oral cavity cancer.
背景
本研究的目的是调查治疗前白细胞总数及分类计数是否能够预测口腔癌患者的预后。
方法
对2004年至2011年间接受治疗的患者进行回顾性分析，评估了202例口腔癌患者的病历。
结果
口腔癌患者中，外周血白细胞（WBC）总数、单核细胞、中性粒细胞计数及中性粒细胞与淋巴细胞比值随临床分期进展而升高。相比之下，淋巴细胞计数下降。此外，病理分期为T4及肿瘤分化差的患者白细胞总数、单核细胞及中性粒细胞计数升高，有淋巴结转移的患者单核细胞计数也升高。而且，治疗前循环单核细胞计数是癌症特异性生存的独立预后因素。
结论
治疗前循环单核细胞计数较高可被视为口腔癌患者有用的预后标志物。
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