与引物模板双链复合物的 KOD 和 9°N DNA 聚合酶的结构。
Structures of KOD and 9°N DNA polymerases complexed with primer template duplex.
机构信息
Department of Chemistry, Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstrasse 10, 78457 Konstanz, Germany.
出版信息
Chembiochem. 2013 Jun 17;14(9):1058-62. doi: 10.1002/cbic.201300175. Epub 2013 Jun 3.
PMID:23733496
Abstract
Replicate it: Structures of KOD and 9°N DNA polymerases, two enzymes that are widely used to replicate DNA with highly modified nucleotides, were solved at high resolution in complex with primer/template duplex. The data elucidate substrate interaction of the two enzymes and pave the way for further optimisation of the enzymes and substrates.
摘要
复制它
结构的 KOD 和 9°N DNA 聚合酶，两种酶被广泛用于复制具有高度修饰的核苷酸的 DNA，在与引物/模板双链体的复合物中以高分辨率解决。这些数据阐明了两种酶的底物相互作用，并为进一步优化酶和底物铺平了道路。
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