Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center Dallas, TX, USA.
Front Neurosci. 2013 May 23;7:85. doi: 10.3389/fnins.2013.00085. eCollection 2013.
Ion channels are critical regulators of neuronal excitability and synaptic function in the brain. Recent evidence suggests that ion channels expressed by neurons within the brain are responsible for regulating energy and glucose homeostasis. In addition, the central effects of neurotransmitters and hormones are at least in part achieved by modifications of ion channel activity. This review focuses on ion channels and their neuronal functions followed by a discussion of the identified roles for specific ion channels in the central pathways regulating food intake, energy expenditure, and glucose balance.
离子通道是大脑中神经元兴奋性和突触功能的关键调节者。最近的证据表明，大脑神经元表达的离子通道负责调节能量和葡萄糖稳态。此外，神经递质和激素的中枢作用至少部分是通过离子通道活性的改变来实现的。本综述重点介绍离子通道及其神经元功能，然后讨论特定离子通道在调节食物摄入、能量消耗和葡萄糖平衡的中枢途径中的作用。
