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Beware of risk for increased false positive rates in genome-wide association studies for phenotypic variability.

作者信息

Shen Xia, Carlborg Orjan

机构信息

Division of Computational Genetics, Department of Clinical Sciences, Swedish University of Agricultural Sciences Uppsala, Sweden ; School of Technology and Business Studies/Statistics, Dalarna University Borlänge, Sweden.

出版信息

Front Genet. 2013 May 21;4:93. doi: 10.3389/fgene.2013.00093. eCollection 2013.

DOI:10.3389/fgene.2013.00093
PMID:23734164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3659368/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd5/3659368/c6d7ba823cd5/fgene-04-00093-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd5/3659368/c6d7ba823cd5/fgene-04-00093-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6cd5/3659368/c6d7ba823cd5/fgene-04-00093-g0001.jpg

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2
FTO genotype is associated with phenotypic variability of body mass index.FTO 基因型与体重指数的表型变异性相关。
Nature. 2012 Oct 11;490(7419):267-72. doi: 10.1038/nature11401. Epub 2012 Sep 16.
3
Inheritance beyond plain heritability: variance-controlling genes in Arabidopsis thaliana.
用于加强亚洲栽培稻等位基因挖掘的12套染色体片段代换系的开发。
Breed Sci. 2023 Jun;73(3):332-342. doi: 10.1270/jsbbs.23006. Epub 2023 Jun 27.
4
An accurate prediction model of digenic interaction for estimating pathogenic gene pairs of human diseases.一种用于估计人类疾病致病基因对的双基因相互作用的精确预测模型。
Comput Struct Biotechnol J. 2022 Jul 7;20:3639-3652. doi: 10.1016/j.csbj.2022.07.011. eCollection 2022.
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Interaction Effects of DRD2 Genetic Polymorphism and Interpersonal Stress on Problematic Gaming in College Students.DRD2 基因多态性与人际应激对大学生问题性游戏的交互作用。
Genes (Basel). 2022 Feb 28;13(3):449. doi: 10.3390/genes13030449.
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