靶向髓系白血病中的组织蛋白酶G
Targeting cathepsin G in myeloid leukemia.
作者信息
Alatrash Gheath
机构信息
Section of Transplant Immunology; Department of Stem Cell Transplantation and Cellular Therapy; University of Texas MD Anderson Cancer Center; Houston, TX USA.
出版信息
Oncoimmunology. 2013 Apr 1;2(4):e23442. doi: 10.4161/onci.23442.
Abstract
Cathepsin G (CG) is a serine protease normally found within the azurophil granules of neutrophils. CG is expressed during the early stages of normal myeloid differentiation and-aberrantly-by myeloid leukemia cells. We have recently identified CG-derived HLA-A*0201-binding peptides that constitute promising targets for the immunotherapy of myeloid leukemia.
摘要
组织蛋白酶G（CG）是一种丝氨酸蛋白酶，通常存在于中性粒细胞的嗜天青颗粒中。CG在正常髓系分化的早期阶段表达，并且在髓系白血病细胞中异常表达。我们最近鉴定出了源自CG的与HLA-A*0201结合的肽段，这些肽段是髓系白血病免疫治疗的有前景的靶点。
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