溃疡性结肠炎中的抗中性粒细胞胞浆抗体（ANCA）：抗组织蛋白酶G和一种新型抗体与难治型相关。
Anti-neutrophil cytoplasmic antibodies (ANCA) in ulcerative colitis: anti-cathepsin G and a novel antibody correlate with a refractory type.
作者信息
Sobajima J, Ozaki S, Okazaki T, Osakada F, Sumita S, Mori K, Nakao K
机构信息
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Japan.
出版信息
Clin Exp Immunol. 1996 Jul;105(1):120-4. doi: 10.1046/j.1365-2249.1996.d01-724.x.
We analysed the clinical significance of ANCA in patients with ulcerative colitis. On either an indirect immunofluorescence assay or an ELISA with fixed neutrophils, 71% (25/35) of the patients were positive for ANCA. However, only half of them reacted with either cathepsin G or lactoferrin. Western blot assays revealed positive bands in 40% (10/25) of the antibody-positive patients. The sizes of the bands detected were approximately 58, 47, 44, 40, and 28 kD. No significant correlation was found between the ANCA positivity and various variables, i.e. disease activity, extent of lesion, or treatment of the disease. The anti-cathepsin G and 28-kD positivity, however, significantly correlated with a refractory type of ulcerative colitis.
我们分析了抗中性粒细胞胞浆抗体（ANCA）在溃疡性结肠炎患者中的临床意义。在间接免疫荧光试验或使用固定中性粒细胞的酶联免疫吸附测定（ELISA）中，71%（25/35）的患者ANCA呈阳性。然而，其中只有一半与组织蛋白酶G或乳铁蛋白发生反应。蛋白质印迹分析显示，40%（10/25）的抗体阳性患者出现阳性条带。检测到的条带大小约为58、47、44、40和28 kDa。未发现ANCA阳性与各种变量之间存在显著相关性，即疾病活动度、病变范围或疾病治疗情况。然而，抗组织蛋白酶G和28-kDa阳性与难治性溃疡性结肠炎显著相关。
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