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癌细胞选择性凋亡中的RIG-I/MAVS信号通路。

The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis.

作者信息

Kaneda Yasufumi

机构信息

Division of Gene Therapy Science; Department of Urology; Department of Pediatric Surgery; Graduate School of Medicine; Osaka University; Yamada-oka, Japan.

出版信息

Oncoimmunology. 2013 Apr 1;2(4):e23566. doi: 10.4161/onci.23566.

DOI:10.4161/onci.23566
PMID:23734313
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3654583/
Abstract

A replication-incompetent hemagglutinating virus of Japan (HVJ) envelope (HVJ-E) induces apoptosis selectively in cancer cells. Fragments of the viral RNA genome transported by HVJ-E are recognized by retinoic acid-inducible gene I (RIG-I) and mitochondrial antiviral signaling (MAVS). Specific pro-apoptotic factor are selectively upregulated in cancer cells downstream of the RIG-I/MAVS pathway.

摘要

一种无复制能力的日本血凝病毒（HVJ）包膜（HVJ-E）可在癌细胞中选择性地诱导细胞凋亡。由HVJ-E转运的病毒RNA基因组片段被视黄酸诱导基因I（RIG-I）和线粒体抗病毒信号蛋白（MAVS）识别。在RIG-I/MAVS途径下游的癌细胞中，特定的促凋亡因子被选择性地上调。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe17/3654583/1229e97f1a86/onci-2-e23566-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe17/3654583/1229e97f1a86/onci-2-e23566-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe17/3654583/1229e97f1a86/onci-2-e23566-g1.jpg

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2
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Nat Rev Cancer. 2011 Sep 23;11(10):726-34. doi: 10.1038/nrc3130.
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