State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
J Nat Prod. 2013 Jun 28;76(6):1166-74. doi: 10.1021/np400276q. Epub 2013 Jun 4.
Eleven new limonoids, turrapubins A-K (1-11), and three new triterpenoids (12-14), along with 14 known compounds, were isolated from the twigs of Turraea pubescens. The structures of 1-14 were elucidated on the basis of NMR and MS analysis. Compounds 12, 16, 18, and 19 exhibited inhibitory activities against lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. In addition, compounds 2, 11, 18, and 26 exhibited inhibitory activities against brine shrimp larvae (Artemia salina) at 100 ppm with the corrected mortality ranging from 81.7% to 100%.
从毛桐的嫩枝中分离得到了 11 个新的柠檬苦素类化合物（1-11），Turrapubins A-K 和 3 个新的三萜类化合物（12-14），以及 14 个已知化合物。基于 NMR 和 MS 分析阐明了 1-14 的结构。化合物 12、16、18 和 19 对 RAW264.7 细胞中脂多糖诱导的一氧化氮生成具有抑制活性。此外，化合物 2、11、18 和 26 在 100ppm 时对卤虫幼虫（Artemia salina）具有抑制活性，校正死亡率范围为 81.7%至 100%。
