State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, 201203, People's Republic of China.
J Nat Prod. 2015 Apr 24;78(4):754-61. doi: 10.1021/np500967k. Epub 2015 Mar 17.
Seven new limonoids, dysomollides A-G (1-7), and two new cycloapotirucallane-type triterpenoids, dysomollins A and B (8 and 9), together with three known compounds, dysoxylumin A (10) and toonapubesins A (11) and B (12), were isolated from the twigs of Dysoxylum mollissimum var. glaberrimum. The structures of 1-9 were elucidated on the basis of spectroscopic methods. Compound 10 showed inhibitory activity against A549 cells with an IC50 value of 2.1 μM, and compound 11 exhibited activity against P388 cells with an IC50 value of 6.7 μM.
从细叶清风藤 Dysoxylum mollissimum var. glaberrimum 的嫩枝中分离得到了 7 个新的柠檬苦素类化合物 dysomollides A-G（1-7）和 2 个新的环阿朴拉烷型三萜 dysomollins A 和 B（8 和 9），以及 3 个已知化合物 dysoxylumin A（10）和 toonapubesins A（11）和 B（12）。基于光谱方法阐明了 1-9 的结构。化合物 10 对 A549 细胞具有抑制活性，IC50 值为 2.1 μM，化合物 11 对 P388 细胞具有抑制活性，IC50 值为 6.7 μM。
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