Department of Science, University of Basilicata, Potenza, Italy.
Department of Translational Medical Sciences, University of Naples "Federico II", Naples, Italy.
Eur J Haematol. 2013 Sep;91(3):265-269. doi: 10.1111/ejh.12152. Epub 2013 Jun 28.
Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and possible evolution to acute leukemia. Occurrence of stem cell defects and of immune-mediated mechanisms was evidenced as relevant for pathophysiology of MDS. Here, we described one case of MDS patient carrying CD14(+) CD56(+) monocytes in bone marrow (BM), in the presence of a defective human leukocyte antigen (HLA)-E expression on peripheral blood (PB) cells and of natural killer (NK) cell expansion in PB and BM. The defective HLA-E expression and the NK expansion are proposed to be relevant for the pathogenesis of myelodysplasia in those patients showing CD14(+) CD56(+) monocytes in BM.
骨髓增生异常综合征（MDS）是一种克隆性疾病，其特征为无效造血，并可能向急性白血病转化。干细胞缺陷和免疫介导的机制的发生被证明与 MDS 的病理生理学相关。在这里，我们描述了一例 MDS 患者骨髓中存在 CD14(+) CD56(+)单核细胞，外周血（PB）细胞 HLA-E 表达缺陷，以及 PB 和 BM 中 NK 细胞扩增。在那些骨髓中出现 CD14(+) CD56(+)单核细胞的 MDS 患者中，推测 HLA-E 表达缺陷和 NK 细胞扩增与骨髓增生异常的发病机制有关。
