Kersey J, Roloff J, Hokeness S, Johnson F L, Nesbit M, Krivit W
Transplantation. 1975 Jun;19(6):475-8. doi: 10.1097/00007890-197506000-00005.
A 15-year-old boy with aplastic anemia was successfully retransplanted with matched sibling bone marrow after failure of a first transplant from the same donor. Cyclophosphamide was used as immunosuppression for the first transplant, and cyclophosphamide plus procarbazine plus antithymocyte globulin were used for the second transplant. Laboratory studies of peripheral blood and bone marrow karyotypes and T and B lymphocytes supported the conclusion that immunosuppression was inadequate for the first transplant, but adequate for the second transplant.
一名15岁再生障碍性贫血男孩在首次接受来自同一供者的移植失败后,成功接受了匹配同胞骨髓的再次移植。第一次移植时使用环磷酰胺作为免疫抑制剂,第二次移植时使用环磷酰胺加甲基苄肼加抗胸腺细胞球蛋白。外周血、骨髓核型以及T和B淋巴细胞的实验室研究支持以下结论:第一次移植的免疫抑制不足,但第二次移植的免疫抑制足够。