丙戊酸抑制原型沙粒病毒 LCMV 的增殖。
Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid.
机构信息
Centro de Biología Molecular Severo Ochoa UAM-CSIC, Cantoblanco, Madrid, Spain.
出版信息
Antiviral Res. 2013 Aug;99(2):172-9. doi: 10.1016/j.antiviral.2013.05.012. Epub 2013 Jun 2.
Abstract
Valproic acid (VPA), a short chain fatty acid commonly used for treatment of neurological disorders, has been shown to inhibit production of infectious progeny of different enveloped viruses including the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV). In this study we have investigated the mechanisms by which VPA inhibits LCMV multiplication in cultured cells. VPA reduced production of infectious LCMV progeny and virus propagation without exerting a major blockage on either viral RNA or protein synthesis, but rather affecting the cell release and specific infectivity of LCMV progeny from infected cells. Our results would support the repurposing of VPA as a candidate antiviral drug to combat arenavirus infections.
摘要
丙戊酸（VPA）是一种短链脂肪酸，常用于治疗神经紊乱，已被证明可抑制不同包膜病毒的传染性子代的产生，包括原型沙粒病毒淋巴细胞性脉络丛脑膜炎病毒（LCMV）。在这项研究中，我们研究了 VPA 抑制培养细胞中 LCMV 增殖的机制。VPA 减少了传染性 LCMV 子代的产生和病毒的传播，而对病毒 RNA 或蛋白质的合成没有产生主要的阻断作用，而是影响了从感染细胞中释放和 LCMV 子代的特定感染性。我们的结果将支持将 VPA 重新用于对抗沙粒病毒感染的候选抗病毒药物。
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