Laboratory for Molecular Design of Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
J Biosci Bioeng. 2013 Nov;116(5):634-7. doi: 10.1016/j.jbiosc.2013.05.001. Epub 2013 Jun 2.
This study focused on the intracellular observation of nanocarriers modified with a mitochondrial targeting signal peptide (MTS). The nanocarriers showed an efficient cellular uptake, and the MTS had a positive effect on their mitochondrial targeting. This is the first report of an intracellular observation of nanocarriers modified with MTS.
本研究专注于经线粒体靶向信号肽（MTS）修饰的纳米载体的细胞内观察。纳米载体表现出高效的细胞摄取，并且 MTS 对其靶向线粒体具有积极作用。这是首例关于经 MTS 修饰的纳米载体的细胞内观察的报道。
