利用设计的荧光猝灭肽检测白念珠菌。
Detection of Candida albicans by using a designed fluorescence-quenched peptide.
机构信息
The Japan Society for the Promotion of Science, Sakyo-ku, Kyoto 606-8502, Japan; Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.
出版信息
J Biosci Bioeng. 2013 Nov;116(5):573-5. doi: 10.1016/j.jbiosc.2013.05.003. Epub 2013 Jun 2.
PMID:23735329
Abstract
Convenient detection of Candida albicans in human bodies is essential to treat patients with candidiasis. In this study, we designed a fluorescence-quenched peptide that emits fluorescence after being cleaved by virulent proteases secreted by C. albicans. The designed peptide will enable easy detection of candidiasis in immunocompromised patients.
摘要
方便地检测人体中的白色念珠菌对于治疗念珠菌病患者至关重要。在这项研究中，我们设计了一种荧光猝灭肽，该肽在被白色念珠菌分泌的毒性蛋白酶切割后会发出荧光。设计的肽将能够方便地检测免疫功能低下患者的念珠菌病。
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