Section of Clinical Chemistry, Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital, Stockholm, Sweden.
Neonatology. 2013;103(4):327-30. doi: 10.1159/000349942. Epub 2013 May 31.
The treatment of preterm newborn rabbits with synthetic surfactants containing simple phospholipid mixtures and peptides gives similar tidal volumes to treatment with poractant alfa (Curosurf®). The addition of both surfactant protein B and C analogs to the phospholipid mixture will stabilize the alveoli, measured as lung gas volumes at end expiration, even if no positive end-expiratory pressure is applied. The effect on lung gas volumes seems to depend on the structure of the peptides as well as the phospholipid composition. It seems that synthetic surfactants containing two peptides and a more complex phospholipid composition will be able to replace natural surfactants within the near future, but more experiments need to be performed before any conclusion can be drawn about the ideal composition of this new generation of synthetic surfactants.
用含有简单磷脂混合物和肽的合成表面活性剂治疗早产新生兔，可获得与使用猪肺磷脂（固尔苏）相似的潮气量。向磷脂混合物中添加两种表面活性蛋白 B 和 C 类似物可稳定肺泡，以呼气末肺气体量（end-expiratory pressure）来衡量，即使不施加正呼气末压力也是如此。这种对肺气体量的影响似乎取决于肽的结构以及磷脂的组成。含有两种肽和更复杂的磷脂组成的合成表面活性剂似乎将在不久的将来能够替代天然表面活性剂，但在得出关于这种新一代合成表面活性剂的理想组成的任何结论之前，还需要进行更多的实验。
