Department of Ultrasonography, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.
Mol Biol Rep. 2013 Apr;40(4):3203-12. doi: 10.1007/s11033-012-2396-z. Epub 2013 Jan 19.
Glutathione S-transferase P1 (GSTP1) is one of the important mutant sites for the cancer risk at present. The conclusions of the published reports on the relationship between GSTP1 A/G gene polymorphism and the risk of breast cancer are still debated. This meta-analysis was performed to evaluate the association between GSTP1 and the risk of breast cancer. The association reports were identified from PubMed and Cochrane Library, and eligible studies were included and synthesized using meta-analysis method. 35 investigations were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and breast cancer susceptibility, consisting of 40,347 subjects (18,665 patients with breast cancer and 21,682 controls). The association between GSTP1 A/G gene polymorphism and breast cancer risk was not found for overall population, Caucasians and Africans. Interestingly, the GSTP1 A/G gene polymorphism was associated with the susceptibility of breast cancer in Asians (G allele: OR = 1.10, 95 % CI: 1.04-1.17, P = 0.001; GG genotype: OR = 1.36, 95 % CI: 1.14-1.62, P = 0.0008; AA genotype: OR = 0.92, 95 % CI: 0.85-0.98, P = 0.02). Furthermore, the GSTP1 A/G gene polymorphism was associated with the susceptibility of breast cancer for the analysis of the controls from hospital. In conclusion, GSTP1 A/G gene polymorphism is associated with the breast cancer susceptibility in Asians. However, more studies on the relationship between GSTP1 A/G gene polymorphism and the risk of breast cancer should be performed in further.
谷胱甘肽 S-转移酶 P1（GSTP1）是目前癌症风险的重要突变位点之一。目前关于 GSTP1 A/G 基因多态性与乳腺癌风险之间的关系的已发表报告的结论仍存在争议。本荟萃分析旨在评估 GSTP1 与乳腺癌风险之间的关系。从 PubMed 和 Cochrane Library 中确定了关联报告，并使用荟萃分析方法纳入和综合了合格的研究。共有 35 项研究纳入了 GSTP1 A/G 基因多态性与乳腺癌易感性的关联分析，共包括 40347 名受试者（18665 名乳腺癌患者和 21682 名对照）。总体人群、白种人和非洲人中未发现 GSTP1 A/G 基因多态性与乳腺癌风险之间存在关联。有趣的是，GSTP1 A/G 基因多态性与亚洲人乳腺癌易感性相关（G 等位基因：OR=1.10，95%CI：1.04-1.17，P=0.001；GG 基因型：OR=1.36，95%CI：1.14-1.62，P=0.0008；AA 基因型：OR=0.92，95%CI：0.85-0.98，P=0.02）。此外，在针对医院对照人群的分析中，GSTP1 A/G 基因多态性与乳腺癌易感性相关。总之，GSTP1 A/G 基因多态性与亚洲人乳腺癌易感性相关。然而，需要进一步开展更多关于 GSTP1 A/G 基因多态性与乳腺癌风险之间关系的研究。
