Koch Alexander, Pfeilschifter Josef, Huwiler Andrea
Pharmazentrum Frankfurt/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany.
Cell Physiol Biochem. 2013;31(6):745-60. doi: 10.1159/000350093. Epub 2013 May 31.
Because of its highly bioactive properties sphingosine 1-phosphate (S1P) is an attractive target for the treatment of several diseases. Since the expression of sphingosine kinases as well as S1P receptors was demonstrated in the kidney, questions about the physiological and pathophysiological functions of S1P in this organ have been raised. In this review, we summarize the current state of knowledge about S1P-mediated functions in the kidney. A special focus is put on S1P modulated signal transduction in renal glomerular and tubular cells and consequences for the development and treatment of several kidney diseases, diabetic nephropathy, glomerulonephritis, ischemia-reperfusion injury, as well as for Wilms tumor progression.
由于其具有高度生物活性，1-磷酸鞘氨醇（S1P）成为治疗多种疾病的一个有吸引力的靶点。鉴于在肾脏中已证实存在鞘氨醇激酶以及S1P受体的表达，关于S1P在该器官中的生理和病理生理功能的问题也随之出现。在这篇综述中，我们总结了目前关于S1P在肾脏中介导的功能的知识现状。特别关注S1P在肾小球和肾小管细胞中调节的信号转导以及对几种肾脏疾病（糖尿病肾病、肾小球肾炎、缺血再灌注损伤以及肾母细胞瘤进展）的发生发展和治疗的影响。
