Khetani Altaf, Riordon Jason, Tiwari Vidhu, Momenpour Ali, Godin Michel, Anis Hanan
School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Opt Express. 2013 May 20;21(10):12340-50. doi: 10.1364/OE.21.012340.
We report that a single hollow core photonic crystal fiber (HC-PCF) can be used for repetitive characterization of multiple samples by Raman spectroscopy. This was achieved by integrating the HC-PCF to a differential pressure system that allowed effective filling, draining and re-filling of samples into a HC-PCF under identical optical conditions. Consequently, high-quality and reliable spectral data could be obtained which were suitable for multivariate analysis (partial least squares). With the present scheme, we were able to accurately predict different concentrations of heparin and adenosine in serum. Thus the detection scheme as presented here paves a path for the inclusion of HC-PCFs in point-of-care technologies and environmental monitoring where rapid sample characterization is of utmost importance.
我们报告，单根空心光子晶体光纤（HC-PCF）可用于通过拉曼光谱对多个样品进行重复表征。这是通过将HC-PCF集成到一个差压系统中来实现的，该系统允许在相同的光学条件下有效地将样品填充、排空并重新填充到HC-PCF中。因此，可以获得适用于多变量分析（偏最小二乘法）的高质量且可靠的光谱数据。采用本方案，我们能够准确预测血清中不同浓度的肝素和腺苷。因此，本文提出的检测方案为将HC-PCF纳入即时检测技术和环境监测铺平了道路，在这些领域中快速的样品表征至关重要。
