Sánchez Ernesto Cuauhtémoc
Hyperbaric Medicine Department, Hospital Agustin O'Horan, SSY, Mérida, Yucatán, Mexico.
Crit Care Nurs Q. 2013 Jul-Sep;36(3):290-8. doi: 10.1097/CNQ.0b013e318294e9e3.
This article outlines the therapeutic mechanisms of hyperbaric oxygenation in acute stroke, based on information obtained from peer-reviewed medical literature. Hyperbaric oxygen is an approved treatment modality for ischemia-reperfusion injury in several conditions. It maintains the viability of the marginal tissue, reduces the mitochondrial dysfunction, metabolic penumbra, and blocks inflammatory cascades observed in acute stroke. Basic and clinical data suggest that hyperbaric oxygen could be a safe and effective treatment option in the management of acute stroke. Further work is needed to clarify its clinical utility when applied within the treatment window of "gold standard" treatments (<3-5 hours).
本文基于从同行评审医学文献中获取的信息，概述了高压氧治疗急性中风的机制。高压氧是几种疾病中缺血再灌注损伤的一种已获批准的治疗方式。它能维持边缘组织的活力，减少线粒体功能障碍、代谢半暗带，并阻断急性中风中观察到的炎症级联反应。基础和临床数据表明，高压氧可能是急性中风治疗中一种安全有效的治疗选择。在“金标准”治疗（<3 - 5小时）的治疗窗口内应用时，还需要进一步的研究来阐明其临床效用。
