人乳头瘤病毒的存在与下咽癌中 p16 的表达。
Presence of human papillomaviruses and p16 expression in hypopharyngeal cancer.
机构信息
Department of Clinical Science, Intervention and Technology, Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
出版信息
Head Neck. 2014 Jan;36(1):107-12. doi: 10.1002/hed.23394. Epub 2013 Sep 12.
BACKGROUND
Patients with hypopharyngeal cancer have a 5-year survival of only 15% to 30%. Human papillomavirus (HPV) is a risk factor and a favorable prognostic factor for oropharyngeal carcinoma and p16 has been suggested as a surrogate marker for HPV-induced cancer. However, few studies have been performed on HPV and p16 in hypopharyngeal cancer.
METHODS
One hundred nine pretreatment hypopharyngeal cancer biopsies were analyzed for presence of HPV and p16 overexpression, and the results were correlated to patient survival.
RESULTS
Of 109 tumors, 7 were HPV-positive (4 HPV16) and 18 overexpressed p16. There was some correlation between survival and HPV status, but not with regard to p16 expression. Notably, all patients with HPV16-positive tumors, also overexpressing p16, lived tumor free for more than 3 years.
CONCLUSION
Our results indicate that HPV-induced hypopharyngeal cancer is rare and that p16 is not a suitable biomarker for presence of HPV in this tumor type.
背景
下咽癌患者的 5 年生存率仅为 15%至 30%。人乳头瘤病毒（HPV）是口咽癌的一个危险因素和预后良好的因素，p16 已被认为是 HPV 诱导癌症的替代标志物。然而，在下咽癌中关于 HPV 和 p16 的研究较少。
方法
分析了 109 例下咽癌术前活检标本中 HPV 和 p16 过表达的存在情况，并将结果与患者的生存情况进行了相关性分析。
结果
在 109 个肿瘤中，有 7 个为 HPV 阳性（4 个为 HPV16），18 个肿瘤 p16 过表达。HPV 状态与生存之间存在一定的相关性，但与 p16 表达无关。值得注意的是，所有 HPV16 阳性肿瘤且 p16 过表达的患者，肿瘤无复发且已存活超过 3 年。
结论
我们的结果表明，HPV 诱导的下咽癌较为罕见，并且 p16 不是该肿瘤类型中存在 HPV 的合适生物标志物。
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