Institute of Chemistry, University of Neuchatel, Ave de Bellevaux 51, 2000 Neuchatel, Switzerland.
Chemistry. 2013 Jun 24;19(26):8378-86. doi: 10.1002/chem.201301348. Epub 2013 Jun 4.
Skin photosensitivity remains one of the main limitations in photodynamic therapy. In this Concept article a strategy to overcome this limitation is described, in which the photosensitizer is hidden inside the hydrophobic cavity of a water-soluble organometallic cage. The metallacage not only protects the photosensitizer from light, it also facilitates its delivery to cancer cells.
皮肤光敏性仍然是光动力疗法的主要限制因素之一。在这篇观点文章中，描述了一种克服这一限制的策略，即将光敏剂隐藏在水溶性有机金属笼的疏水性腔内。金属笼不仅可以保护光敏剂免受光照，还可以促进其递送至癌细胞。
