Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Lab, Capital Medical University, Beijing, China.
Invest Ophthalmol Vis Sci. 2013 Jul 12;54(7):4659-65. doi: 10.1167/iovs.12-10991.
To describe characteristics of central serous chorioretinopathy (CSC) imaged by optical coherence tomography-assisted enhanced depth imaging (EDI-OCT).
The prospective observational case series study consisted of patients with acute or chronic CSC. All subjects underwent fundus fluorescein angiography, indocyanine green angiography (ICGA), and EDI-OCT.
The study included 68 eyes (68 patients) with 35 eyes showing signs of acute CSC. Mean subfoveal choroidal thickness, 478 ± 114 μm, was larger than the normative value from the beijing eye study 2011 (254 ± 107 μm) on the same ethnic group. In the hyperfluorescent ICGA areas, EDI-OCT revealed a thinning of the inner choroidal layers and enlargement of the underlying hyporeflective lumina in all eyes. the diameter of the hyporeflective lumina (mean: 330 ± 103 μm) was significantly (P < 0.001) associated with subfoveal choroidal thickness (correlation coefficient [r]: 0.68). An RPE detachment was detected in 36 (53%) eyes. A double-layer sign defined as an undulated RPE layer and intact underlying Bruch's membrane (seen in 51 [75%] eyes) was significantly (P = 0.025) more often in the chronic CSC group (29/33; 87%) than in the acute CSC group (22/35; 63%). Prevalence of an RPE microrip (8/68 [12%] eyes) did not differ (P = 0.14) between the chronic CSC group (6/33; 18%) and the acute CSC group (2/35; 5.7%).
CSC is characterized by a thinned inner choroidal layer and enlarged underlying hyporeflective choroidal lumina in all eyes, in addition to a dome-shaped RPE elevation, a double-layer sign of the RPE/Bruch's membrane complex, and RPE microrips in some eyes. EDI-OCT may be helpful in the diagnosis of CSC.
描述光学相干断层扫描辅助增强深度成像（EDI-OCT）成像的中心性浆液性脉络膜视网膜病变（CSC）的特征。
这项前瞻性观察性病例系列研究包括急性或慢性 CSC 患者。所有患者均行眼底荧光血管造影、吲哚青绿血管造影（ICGA）和 EDI-OCT 检查。
该研究纳入了 68 只眼（68 例），其中 35 只眼有急性 CSC 表现。平均黄斑下脉络膜厚度为 478±114μm，大于同种族人群的 2011 年北京眼研究的正常值（254±107μm）。在高荧光的 ICGA 区域，EDI-OCT 显示所有眼的内层脉络膜变薄，下方低反射腔扩大。低反射腔的直径（平均值：330±103μm）与黄斑下脉络膜厚度显著相关（相关系数[r]：0.68）（P<0.001）。36 只眼（53%）检测到 RPE 脱离。双层征定义为波浪状的 RPE 层和完整的下方 Bruch 膜（51 只眼[75%]可见），在慢性 CSC 组（29/33；87%）中明显比急性 CSC 组（22/35；63%）更常见（P=0.025）。RPE 微裂孔的发生率（68 只眼中的 8 只眼[12%]）在慢性 CSC 组（6/33；18%）和急性 CSC 组（2/35；5.7%）之间无差异（P=0.14）。
CSC 的特征是所有眼中内层脉络膜变薄，下方低反射腔扩大，此外还存在 RPE 隆起的丘状形态、RPE/Bruch 膜复合体的双层征和一些眼中的 RPE 微裂孔。EDI-OCT 可能有助于 CSC 的诊断。
