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中心性浆液性脉络膜视网膜病变（CSCR）中视网膜色素上皮（RPE）的高分辨率自适应光学-经巩膜泛光照明（AO-TFI）成像。

High-resolution adaptive optics-trans-scleral flood illumination (AO-TFI) imaging of retinal pigment epithelium (RPE) in central serous chorioretinopathy (CSCR).

作者信息

Govindahari Vishal, Dornier Rémy, Ferdowsi Sohrab, Moser Christophe, Mantel Irmela, Behar-Cohen Francine, Kowalczuk Laura

机构信息

Department of Retina, Pushpagiri Eye Institute, Hyderabad, 500026, India.

INSERM UMRS 1138 From Physiopathology of Ocular Diseases to Clinical Developments, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie - Paris 6, 75006, Paris, France.

出版信息

Sci Rep. 2024 Jun 13;14(1):13689. doi: 10.1038/s41598-024-64524-4.

DOI:10.1038/s41598-024-64524-4
PMID:38871803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11176374/
Abstract

This study aims to correlate adaptive optics-transscleral flood illumination (AO-TFI) images of the retinal pigment epithelium (RPE) in central serous chorioretinopathy (CSCR) with standard clinical images and compare cell morphological features with those of healthy eyes. After stitching 125 AO-TFI images acquired in CSCR eyes (including 6 active CSCR, 15 resolved CSCR, and 3 from healthy contralateral), 24 montages were correlated with blue-autofluorescence, infrared and optical coherence tomography images. All 68 AO-TFI images acquired in pathological areas exhibited significant RPE contrast changes. Among the 52 healthy areas in clinical images, AO-TFI revealed a normal RPE mosaic in 62% of the images and an altered RPE pattern in 38% of the images. Morphological features of the RPE cells were quantified in 54 AO-TFI images depicting clinically normal areas (from 12 CSCR eyes). Comparison with data from 149 AO-TFI images acquired in 33 healthy eyes revealed significantly increased morphological heterogeneity. In CSCR, AO-TFI not only enabled high-resolution imaging of outer retinal alterations, but also revealed RPE abnormalities undetectable by all other imaging modalities. Further studies are required to estimate the prognosis value of these abnormalities. Imaging of the RPE using AO-TFI holds great promise for improving our understanding of the CSCR pathogenesis.

摘要

本研究旨在将中心性浆液性脉络膜视网膜病变（CSCR）患者视网膜色素上皮（RPE）的自适应光学 - 经巩膜泛光照明（AO - TFI）图像与标准临床图像进行关联，并将细胞形态特征与健康眼睛的特征进行比较。在拼接了125张CSCR患者眼睛获取的AO - TFI图像（包括6例活动性CSCR、15例已缓解的CSCR以及3例对侧健康眼的图像）后，将24幅拼接图像与蓝色自发荧光、红外和光学相干断层扫描图像进行关联。在病理区域获取的所有68张AO - TFI图像均显示出RPE对比度的显著变化。在临床图像的52个健康区域中，AO - TFI显示62%的图像中RPE镶嵌正常，38%的图像中RPE模式改变。在54张描绘临床正常区域的AO - TFI图像（来自12例CSCR患者眼睛）中对RPE细胞的形态特征进行了量化。与33例健康眼睛获取的149张AO - TFI图像数据相比，发现形态异质性显著增加。在CSCR中，AO - TFI不仅能够对外层视网膜改变进行高分辨率成像，还能揭示其他所有成像方式均无法检测到的RPE异常。需要进一步研究来评估这些异常的预后价值。使用AO - TFI对RPE进行成像对于增进我们对CSCR发病机制的理解具有很大的前景。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/f44bc6900306/41598_2024_64524_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/bc7673b1159c/41598_2024_64524_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/0f544564e636/41598_2024_64524_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/7bf2007174dc/41598_2024_64524_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/7b05c7a07d33/41598_2024_64524_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/2745f3a1a01b/41598_2024_64524_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/f718eb50bf8a/41598_2024_64524_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/100b19cf99af/41598_2024_64524_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/f44bc6900306/41598_2024_64524_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/bc7673b1159c/41598_2024_64524_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/0f544564e636/41598_2024_64524_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/7bf2007174dc/41598_2024_64524_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/7b05c7a07d33/41598_2024_64524_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/2745f3a1a01b/41598_2024_64524_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/f718eb50bf8a/41598_2024_64524_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/100b19cf99af/41598_2024_64524_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/28fb/11176374/f44bc6900306/41598_2024_64524_Fig8_HTML.jpg

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High-resolution adaptive optics-trans-scleral flood illumination (AO-TFI) imaging of retinal pigment epithelium (RPE) in central serous chorioretinopathy (CSCR).

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引用本文的文献

[1]
Adaptive Optics-Transscleral Flood Illumination Imaging of Retinal Pigment Epithelium in Dry Age-Related Macular Degeneration.

Cells. 2025-4-24

本文引用的文献

[1]
Phototoxicity of low doses of light and influence of the spectral composition on human RPE cells.

Sci Rep. 2024-3-21

[2]
Pathomechanisms in central serous chorioretinopathy: A recent update.

Int J Retina Vitreous. 2023-1-20

[3]
In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes.

Ophthalmol Sci. 2022-10-19

[4]
Autofluorescent hyperreflective foci on infrared autofluorescence adaptive optics ophthalmoscopy in central serous chorioretinopathy.

Am J Ophthalmol Case Rep. 2022-10-31

[5]
Histologic Cell Shape Descriptors for the Retinal Pigment Epithelium in Age-Related Macular Degeneration: A Comparison to Unaffected Eyes.

Transl Vis Sci Technol. 2022-8-1

[6]
Human Foveal Cone and RPE Cell Topographies and Their Correspondence With Foveal Shape.

Invest Ophthalmol Vis Sci. 2022-2-1

[7]
CENTRAL SEROUS CHORIORETINOPATHY: High-Resolution Imaging of Asymptomatic Fellow Eyes Using Adaptive Optics Scanning Laser Ophthalmoscopy.

Retina. 2022-2-1

[8]
Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy.

Pharmaceutics. 2021-7-21

[9]
Venous overload choroidopathy: A hypothetical framework for central serous chorioretinopathy and allied disorders.

Prog Retin Eye Res. 2022-1

[10]
Integrating adaptive optics-SLO and OCT for multimodal visualization of the human retinal pigment epithelial mosaic.

Biomed Opt Express. 2021-2-17

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