State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Yale College, Yale University, New Haven, CT, USA.
Transl Vis Sci Technol. 2023 Sep 1;12(9):17. doi: 10.1167/tvst.12.9.17.
To evaluate differences in the choroidal vortex vein drainage system (VV) in eyes between patients with central serous chorioretinopathy (CSC) and unaffected individuals using ultra-widefield optical coherence tomography angiography (UWF-OCTA).
In this cross-sectional observational study, 40 eyes of patients with CSC and 28 eyes of healthy volunteers were included. The analysis involved the use of UWF-OCTA to analyze the proportion of the choroidal vortex vein drainage system (VV%), choroidal thickness, choroidal vascular volume (CVV), and choroidal vascularity index (CVI) of the VV in each drainage quadrant. The location relationship between the leakage points in fluorescein angiography and the VV was also explored.
A within-group analysis of VV% showed a statistically significant difference in the CSC group (P < 0.001) but not in the control group (P = 0.270). Compared to healthy eyes, CSC eyes had a significantly larger CVV and higher CVI in all regions (all P < 0.05). The superotemporal (ST) drainage system had the largest CVV and thickest choroidal layer among the four drainage quadrants (all P < 0.05) in CSC eyes. The leakage rate in the ST quadrant was significantly higher than that in the inferotemporal quadrant (P < 0.001).
CSC eyes have an asymmetric vortex vein drainage system, with relative hyperperfusion in all VV. Further, the preferential drainage route of the submacular choroid may be the ST drainage system in CSC eyes.
Targeting the imbalanced drainage system could be a potential therapeutic approach for CSC.
利用超广角光相干断层扫描血管造影术（UWF-OCTA）评估中心性浆液性脉络膜视网膜病变（CSC）患者与正常眼之间脉络膜涡静脉引流系统（VV）的差异。
本横断面观察性研究纳入了 40 只 CSC 眼和 28 只健康志愿者眼。分析包括使用 UWF-OCTA 分析每个引流象限中脉络膜涡静脉引流系统（VV%）、脉络膜厚度、脉络膜血管容积（CVV）和脉络膜血管指数（CVI）的比例。还探讨了荧光素血管造影中渗漏点与 VV 的位置关系。
VV%的组内分析显示 CSC 组有统计学显著差异（P < 0.001），但对照组无统计学差异（P = 0.270）。与正常眼相比，CSC 眼在所有区域的 CVV 均较大，CVI 均较高（均 P < 0.05）。在 CSC 眼中，四个引流象限中，SV 象限的 CVV 最大，脉络膜最厚（均 P < 0.05）。CSC 眼中 SV 象限的渗漏率明显高于 IT 象限（P < 0.001）。
CSC 眼的涡静脉引流系统不对称，所有 VV 均存在相对高灌注。此外，CSC 眼脉络膜下黄斑区的优先引流途径可能是 SV 引流系统。
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