Wang Zhong-Ming, Liu Ya-Bing, Jin Qi-Chen, Wang Xue-Qi, Dai Meng, Shao Hui, Zhao Wen-Ping, Dong Qiu-Li, Wang Shu-Ping, Zhang Hai-Tao, Kong Li-Cha, Liu Shao-Yun, Wang Dong-Ying
Second Department of Cardiology, General Hospital of North China Petroleum Administration;
Exp Ther Med. 2013 May;5(5):1363-1366. doi: 10.3892/etm.2013.980. Epub 2013 Feb 27.
The aim of this study was to explore the chronergy of intravenous recombinant streptokinase (r-SK) in patients with acute myocardial infarction (AMI). A total of 114 patients were divided into two groups according to the time of AMI onset: the morning onset (6:01-12:00, n=53) and non-morning onset (12:01-06:00, n=61) groups. The recanalization rate was recorded, as well as anticoagulant and fibrinolytic indices. Statistical analysis was performed to evaluate the recanalization rate following thrombolysis, as well as the anticoagulant and fibrinolytic activities. The recanalization rates following thrombolysis in the morning onset and non-morning onset groups were 60.4 and 82.0%, respectively (P<0.05). The level of plasminogen activator inhibitor-1 (PAI-1) antigen was significantly higher in the morning onset group compared with that in the non-morning onset group (P<0.05). This indicated a resistance to r-SK thrombolysis in the morning at the early stage of AMI, which possibly correlates with increased PAI-1 antigen levels and activity.
本研究旨在探讨急性心肌梗死（AMI）患者静脉注射重组链激酶（r-SK）的时效关系。根据AMI发病时间将114例患者分为两组：晨起发病组（6:01-12:00，n=53）和非晨起发病组（12:01-06:00，n=61）。记录再通率以及抗凝和纤溶指标。进行统计分析以评估溶栓后的再通率以及抗凝和纤溶活性。晨起发病组和非晨起发病组溶栓后的再通率分别为60.4%和82.0%（P<0.05）。晨起发病组纤溶酶原激活物抑制剂-1（PAI-1）抗原水平显著高于非晨起发病组（P<0.05）。这表明在AMI早期晨起时对r-SK溶栓存在抵抗，这可能与PAI-1抗原水平和活性增加有关。
