Chatterjee Manavi, Jaiswal Manoj, Palit Gautam
Neuropharmacology Unit, Division of Pharmacology, Central Drug Research Institute, CSIR, Uttar Pradesh, Lucknow 226001, India.
ISRN Psychiatry. 2012 Jan 12;2012:595141. doi: 10.5402/2012/595141. Print 2012.
Previous studies have shown that the administration of NMDA antagonist can induce negative symptoms of schizophrenia which can be tested through the enhanced immobility observed in the forced swim test (FST). In the present study, we have compared the effects of acute as well as chronic administration of a noncompetitive NMDA receptor antagonist, ketamine on FST, and another behaviour despair model, tail suspension test (TST). Our observations suggest that chronic ketamine administration induced a state of enhanced immobility in FST, but such findings were not replicated in the TST model. Further, in FST, treatment with clozapine reverses the ketamine-induced immobility in mice, whereas it enhances the immobility duration in the TST model. However, haloperidol showed no protective effects in both models. The data suggests that although both of these tests show common behavioural measure of feeling despair, however, the underlying pathophysiology seems to be different. Hence, forced swim test but not tail suspension test can be used as a model of negative symptom of psychosis in mice.
先前的研究表明，给予NMDA拮抗剂可诱发精神分裂症的阴性症状，这可通过强迫游泳试验（FST）中观察到的不动时间延长来检测。在本研究中，我们比较了非竞争性NMDA受体拮抗剂氯胺酮急性和慢性给药对FST以及另一种行为绝望模型——悬尾试验（TST）的影响。我们的观察结果表明，慢性给予氯胺酮会在FST中诱发不动时间延长的状态，但在TST模型中未重复出现此类结果。此外，在FST中，用氯氮平治疗可逆转氯胺酮诱导的小鼠不动状态，而在TST模型中，它会延长不动时间。然而，氟哌啶醇在两种模型中均未显示出保护作用。数据表明，尽管这两种试验都显示出了衡量绝望情绪的共同行为指标，但潜在的病理生理学似乎有所不同。因此，强迫游泳试验而非悬尾试验可作为小鼠精神病阴性症状的模型。
