Ahmed Tazeen J, Montero-Melendez Trinidad, Perretti Mauro, Pitzalis Costantino
William Harvey Research Institute, Barts and The London School of Medicine, Charterhouse Square, London EC1M 6BQ, UK.
Int J Inflam. 2013;2013:985815. doi: 10.1155/2013/985815. Epub 2013 May 7.
The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature. Melanocortins are peptides endowed with considerable promise with their proresolution and anti-inflammatory effects in preclinical models of inflammatory disease, with tissue protective effects. These peptides and their targets are appealing because they can be seen as a natural way of inducing these effects as they harness endogenous pathways of control. Whereas most of the information generated about these mediators derives from several acute models of inflammation (such as zymosan induced peritonitis), there is some indication that these mediators may inhibit chronic inflammation by modulating cytokines, chemokines, and leukocyte apoptosis. In addition, proresolving mediators and their mimics have often been tested alongside therapeutic protocols, hence have been tested in settings more relevant to real life clinical scenarios. We provide here an overview on some of these mediators with a focus on melanocortin peptides and receptors, proposing that they may unveil new opportunities for innovative treatments of inflammatory arthritis.
现在已知炎症的消退是一个活跃的过程，有多种性质为脂质和蛋白质的介质参与其中。促黑素细胞激素是一类肽，在炎症性疾病的临床前模型中具有显著的促消退和抗炎作用以及组织保护作用，因而颇具前景。这些肽及其靶点很有吸引力，因为它们利用内源性控制途径，可被视为诱导这些作用的自然方式。尽管有关这些介质的大部分信息来自多种急性炎症模型（如酵母聚糖诱导的腹膜炎），但有迹象表明这些介质可能通过调节细胞因子、趋化因子和白细胞凋亡来抑制慢性炎症。此外，促消退介质及其模拟物经常与治疗方案一起进行测试，因此是在更贴近现实临床场景的环境中进行测试的。我们在此概述其中一些介质，重点关注促黑素细胞激素肽和受体，提出它们可能为炎症性关节炎的创新治疗带来新机遇。
