Hiura M, Yorishima M, Tanaka M, Yokoyama T, Myoga H, Chiba T, Nakanishi Y
Department of Obstetrics and Gynecology, Shikoku Cancer Center Hospital, Ehime.
Nihon Sanka Fujinka Gakkai Zasshi. 1990 May;42(5):471-8.
In order to evaluate the clinical significance of multiple tumor markers, plasma levels of carcino-embryonic antigen (CEA), squamous cell carcinoma-related antigen (SCC), tissue polypeptide antigen (TPA) and immunosuppressive acidic protein (IAP) were measured before and after treatment in 136 patients (89 surgery cases and 47 radiotherapy cases). The patients had invasive cervical carcinoma (stages I-IV). The effect of radiotherapy was examined by cytology and biopsies obtained by colposcopy. For CEA, SCC and TPA there was a significant reduction (p less than 0.01) in values between the pretreatment and posttreatment periods, but plasma IAP was transiently increased after operation. Cytology and histology revealed negative rates of 95.6% and 86.7%, respectively, after radiotherapy. Regarding recurrence, for the negative groups and positive groups plasma CEA, SCC, TPA and IAP were determined in 24 patients with stage IIIb before radiotherapy. Only the CEA concentration showed a good correlation with the outcome (p less than 0.01). Effective serial plasma determinations of CEA, SCC and TPA in patients with cervical carcinoma following therapy may often be useful in the evaluation of therapy as well as in the earlier detection of recurrent disease.
为了评估多种肿瘤标志物的临床意义，我们检测了136例患者（89例手术患者和47例放疗患者）治疗前后血浆中癌胚抗原（CEA）、鳞状细胞癌相关抗原（SCC）、组织多肽抗原（TPA）和免疫抑制酸性蛋白（IAP）的水平。这些患者患有浸润性宫颈癌（I-IV期）。通过细胞学检查和阴道镜活检来评估放疗效果。对于CEA、SCC和TPA，治疗前和治疗后的值有显著降低（p<0.01），但术后血浆IAP短暂升高。放疗后细胞学和组织学检查显示阴性率分别为95.6%和86.7%。关于复发情况，在放疗前对24例IIIb期患者的阴性组和阳性组测定了血浆CEA、SCC、TPA和IAP。只有CEA浓度与预后有良好的相关性（p<0.01）。对宫颈癌患者治疗后进行有效的CEA、SCC和TPA系列血浆检测，通常有助于评估治疗效果以及早期发现复发性疾病。
