Jarosz-Chobot Przemysława, Polańska Joanna, Myśliwiec Małgorzata, Szadkowska Agnieszka, Fendler Wojciech, Kamińska Halla, Chumiecki Miron, Mianowska Beata, Techmańska Ilona, Sztangierska Beata, Młynarski Wojciech
Department of paediatrics, Medical University of Silesia, Poland.
Pediatr Endocrinol Diabetes Metab. 2012;18(4):125-9.
Glycated haemoglobin is currently a golden standard of evaluation of metabolic control of diabetes. According to the Evidence based Medicine data, better metabolic control of diabetes decreases the prevalence of chronic complications.
to analyse HbA1c in children with a longer duration of type 1 diabetes mellitus (t1DM).
We analysed an epidemiological database (2006-2009) of 7783 HbA1c values of 996 children (465 girls) with t1DM treated at three academic centres (Gdańsk, Łódź, Katowice) in Poland. the mean age was 13.04±3.43 years and the mean duration of diabetes was 6.93±2.33 years.
the overall mean HbA1c was 7.6±1.5% (by age groups: 7.0±0.8%, 2-5 yrs; 7.1±1.0%, 6-10 yrs; 7.8±1.7%, 11-19 yrs) without gender-related differences. HbA1c increased significantly with increasing age and t1DM duration. HbA1c values differed significantly between the centres. A group of 455 (55.7%) children reached a stable course of diabetes with HbA1c <7.5%, and 110 (13.5%) had HbA1c levels >9%. The mean HbA1c ?6.5% was found in 150 children (18.4%).
In more than 50% of Polish children with longer t1DM duration, the international target of glycaemic control (HbA1c) is achieved; however, only 18% of them reached Polish national target. Age, t1DM duration and centre-specific factors influence the HbA1c values.
糖化血红蛋白目前是评估糖尿病代谢控制的金标准。根据循证医学数据，更好的糖尿病代谢控制可降低慢性并发症的患病率。
分析1型糖尿病（t1DM）病程较长儿童的糖化血红蛋白（HbA1c）水平。
我们分析了波兰三个学术中心（格但斯克、罗兹、卡托维兹）治疗的996例t1DM儿童（465名女孩）的7783个HbA1c值的流行病学数据库（2006 - 2009年）。平均年龄为13.04±3.43岁，平均糖尿病病程为6.93±2.33年。
总体平均HbA1c为7.6±1.5%（按年龄组：2 - 5岁为7.0±0.8%；6 - 10岁为7.1±1.0%；11 - 19岁为7.8±1.7%），无性别差异。HbA1c随年龄和t1DM病程增加而显著升高。各中心之间HbA1c值差异显著。455名（55.7%）儿童糖尿病病情稳定，HbA1c<7.5%，110名（13.5%）儿童HbA1c水平>9%。150名儿童（18.4%）的平均HbA1c≤6.5%。
在病程较长的波兰t1DM儿童中，超过50%达到了血糖控制的国际目标（HbA1c）；然而，只有18%达到了波兰国家目标。年龄、t1DM病程和中心特定因素影响HbA1c值。
