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波兰患者真实生活条件下间歇性扫描连续血糖监测数据:与世界范围数据相比,扫描更频繁,血糖控制更好。

Intermittently Scanned Continuous Glucose Monitoring Data of Polish Patients from Real-Life Conditions: More Scanning and Better Glycemic Control Compared to Worldwide Data.

机构信息

Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland.

Department of Internal Medicine, Diabetology and Nephrology, Medical University of Silesia, Katowice, Poland.

出版信息

Diabetes Technol Ther. 2021 Aug;23(8):577-585. doi: 10.1089/dia.2021.0034. Epub 2021 Apr 21.

Abstract

Randomized trials and observational studies have shown that the use of FreeStyle Libre intermittently scanned continuous glucose monitoring system (isCGMS) is associated with improved glycemic indices and quality of life. In this retrospective, real-world data analysis, we described country-specific glucometrics among isCGMS users from Poland and compared them with international data. The analyzed time period for the Polish data ranged between August 2016 and August 2020, and the analyzed time period for the international data ranged from September 2014 to August 2020. Data from the Polish population were collected from 10,679 readers and 92,627 sensors with 113 million automatically recorded glucose readings. The worldwide database included information from 981,876 readers and 11,179,229 sensors with 13.1 billion glucose readings. On average, the users of isCGMS from Poland performed substantially more scans/day (21.2 ± 14.2 vs. 13.2 ± 10.7), achieved lower eHbA1c (7.0% ± 1.2% vs. 7.5% ± 1.5%), and spent more time-in-range (TIR) (64.2% ± 17.3% vs. 58.1% ± 20.3%) and less time-above-range (TAR) (29.7% ± 18.0% vs. 36.6% ± 21.3%) ( < 0.0001 for all comparisons). Moreover, they were more likely to achieve TIR >70% (36.3% vs. 28.8%), but spent more time-below-range (TBR) (4.7% vs. 3.6%). Our results confirmed that analyzed glucometrics improve as the scan rate frequency increases. However, at a similar scanning frequency to the comparative group, users from Poland achieved lower eHbA1c, higher TIR, and lower TAR, but higher TBR. We report more scanning and better glycemic control in isCGMS users in Poland than worldwide. The cause of this observation remains unknown. Our data also show that in real-life practice, a large number of patients may be willing to perform scanning more frequently than it is usually assumed.

摘要

随机试验和观察性研究表明,使用 FreeStyle Libre 间歇性扫描连续血糖监测系统(isCGMS)与改善血糖指标和生活质量有关。在这项回顾性、真实世界数据分析中,我们描述了波兰 isCGMS 用户的特定国家血糖指标,并将其与国际数据进行了比较。波兰数据的分析时间段在 2016 年 8 月至 2020 年 8 月之间,国际数据的分析时间段在 2014 年 9 月至 2020 年 8 月之间。波兰人群的数据来自 10,679 个阅读器和 92,627 个传感器,共记录了 1.13 亿次自动血糖读数。全球数据库包括来自 981,876 个阅读器和 11,179,229 个传感器的信息,记录了 131 亿次血糖读数。平均而言,波兰 isCGMS 用户每天进行的扫描次数明显更多(21.2 ± 14.2 次 vs. 13.2 ± 10.7 次),实现的 eHbA1c 更低(7.0% ± 1.2% vs. 7.5% ± 1.5%),TIR 时间更长(64.2% ± 17.3% vs. 58.1% ± 20.3%),TAR 时间更短(29.7% ± 18.0% vs. 36.6% ± 21.3%)(所有比较均<0.0001)。此外,他们更有可能实现 TIR >70%(36.3% vs. 28.8%),但 TBR 时间更长(4.7% vs. 3.6%)。我们的结果证实,随着扫描频率的增加,分析后的血糖指标会得到改善。然而,在与对照组相似的扫描频率下,波兰的使用者实现了更低的 eHbA1c、更高的 TIR 和更低的 TAR,但 TBR 更高。我们报告了波兰的 isCGMS 用户比全球范围内进行了更多的扫描和更好的血糖控制。这种观察结果的原因尚不清楚。我们的数据还表明,在实际实践中,大量患者可能愿意比通常假设的更频繁地进行扫描。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4607/8377514/594b98ffc67e/dia.2021.0034_figure1.jpg

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