Àmbit Atenció Primària Barcelona, Institut Català de la Salut, Barcelona, Spain,
Community Ment Health J. 2014 Jan;50(1):81-95. doi: 10.1007/s10597-013-9614-6. Epub 2013 Jun 6.
Patients with severe mental illness have higher prevalences of cardiovascular risk factors (CRF). The objective is to determine whether interventions to modify lifestyles in these patients reduce anthropometric and analytical parameters related to CRF in comparison to routine clinical practice. Systematic review of controlled clinical trials with lifestyle intervention in Medline, Cochrane Library, Embase, PsycINFO and CINALH. Change in body mass index, waist circumference, cholesterol, triglycerides and blood sugar. Meta-analyses were performed using random effects models to estimate the weighted mean difference. Heterogeneity was determined using i(2) statistical and subgroups analyses. 26 studies were selected. Lifestyle interventions decrease anthropometric and analytical parameters at 3 months follow up. At 6 and 12 months, the differences between the intervention and control groups were maintained, although with less precision. More studies with larger samples and long-term follow-up are needed.
患有严重精神疾病的患者心血管危险因素（CRF）的患病率较高。目的是确定与常规临床实践相比，针对这些患者的生活方式干预措施是否可以降低与 CRF 相关的人体测量和分析参数。在 Medline、Cochrane Library、Embase、PsycINFO 和 CINALH 中对具有生活方式干预的对照临床试验进行系统评价。体重指数、腰围、胆固醇、甘油三酯和血糖的变化。使用随机效应模型进行荟萃分析，以估计加权均数差。使用 I(2)统计和亚组分析确定异质性。选择了 26 项研究。生活方式干预可降低 3 个月随访时的人体测量和分析参数。在 6 个月和 12 个月时，干预组和对照组之间的差异仍然存在，尽管精度较低。需要更多具有更大样本量和长期随访的研究。
