Foguet-Boreu Quintí, Vilamala-Orra Mireia, Vaqué-Crusellas Cristina, Roura-Poch Pere, Assens Tauste Montse, Bori Vila Judit, Santos-López Jose Manuel, Del Río Sáez Ruben
Multidisciplinary Research Group in Mental Health, Department of Psychiatry, Vic University Hospital, 08500, Vic, Spain.
Department of Psychiatry, Vic University Hospital, 08500, Vic, Spain.
BMC Res Notes. 2022 Mar 29;15(1):122. doi: 10.1186/s13104-022-06005-3.
The aim of this study is to determine the metabolic impact of a nutrition education program on metabolic parameters and the presence of metabolic syndrome (MetS).
Seventy-four patients were included (mean age, 48.7 years [Standard deviation, SD: 10.8], 55.4% men). The diagnoses of SMD were 37.8% schizophrenia and related disorders; 29.7% bipolar disorder; 25.7% depressive disorder; 4.1% personality disorders; and 2.7% obsessive compulsive disorders. Thirty-seven individuals were distributed in both the intervention group (IG) and the control group (CG). In the IG the presence of MetS was 56.3% and in the CG 46.7%, with no statistically significant difference (p = 0.309). At the end of the study, glomerular filtrate decreased in the IG, body mass index and abdominal perimeter increased in both groups, and there were no changes in metabolic parameters between the groups. Between the baseline and the end of the study, there was no increase in the number of patients diagnosed with MetS (14 at both points); and in the CG the increase was from 8 to 12 (p = 0.005). An intervention based on fruit and vegetable intake could prevent progression to MetS in individuals with SMD, decreasing the likelihood of cardiovascular disease. Trial registration The trial was retrospectively registered on International Standard Randomised Controlled Trial Number (ISRCTN) Register on 11 March 2022 (ISRCTN12024347).
本研究旨在确定营养教育计划对代谢参数和代谢综合征（MetS）存在情况的代谢影响。
纳入74例患者（平均年龄48.7岁[标准差，SD：10.8]，男性占55.4%）。精神分裂症及相关障碍的诊断率为37.8%；双相情感障碍为29.7%；抑郁症为25.7%；人格障碍为4.1%；强迫症为2.7%。37人被分配到干预组（IG）和对照组（CG）。IG组中MetS的存在率为56.3%，CG组为46.7%，无统计学显著差异（p = 0.309）。研究结束时，IG组肾小球滤过率下降，两组体重指数和腹围均增加，两组间代谢参数无变化。在基线和研究结束之间，被诊断为MetS的患者数量没有增加（两个时间点均为14例）；CG组中，该数量从8例增加到12例（p = 0.005）。基于水果和蔬菜摄入量的干预可预防患有严重精神疾病（SMD）的个体进展为MetS，降低心血管疾病的可能性。试验注册 该试验于2022年3月11日在国际标准随机对照试验编号（ISRCTN）注册库上进行了回顾性注册（ISRCTN12024347）。
